Disease Overview
Cleft lip is oral and maxillofacial common congenital malformation, a rate of about 1:1000. Normal fetus, in the fifth week after the beginning of some embryos from each other integration processes gradually formed face, such as failure to normal development can occur deformities, including cleft lip.
Pathological causes
Caused obstacles to the development and integration of the precise causes and pathogenesis, has not yet fully understand. According to a large number of experimental research and epidemiological survey showed that many factors may influence the result rather than a single factor. In summary, genetic factors can be divided into two areas and environmental factors, and nutrition, genetic, infections, endocrine, and other factors.
1. Genetic factors in patients with cleft lip can be found in their direct relatives or next Shito Shito relatives in a similar deformity occurred, thus that cleft lip and genetic deformities have a certain clearance Shito. Epidemiological investigations showed that: in straight Shito relatives in the cleft lip deformity, its incidence of cleft lip and future generations of the family than in those without e cleft deformities higher. Genetics of cleft lip is also believed that many genetic diseases.
2. Major environmental factors that embryonic growth and development of the environment, the mother of the physiological status of the embryo development constitutes the environmental conditions. Therefore, in the first three months of pregnancy, when the mother’s physiological state by the invasion or interference, it may affect fetal growth and development of the maxillofacial.
(1) lack of nutrition in experimental animal studies in mice found that a lack of vitamin A, B2 and folic acid and other food ingredients, you can have a deformity, such as cleft lip, but also because of a lack of human whether such material which is also the incidence of congenital malformations Not very clear. So in early pregnancy may be the lack of nutrition is one of the incidence incentives.
(2) infection and injury in early pregnancy if the mother suffered some damage, in particular, can cause the uterus and its adjacent parts of injury, such as improper or incomplete abortion unscientific drugs such as abortion, can affect the development of embryos Incurred deformities. Mother suffering from infection of diseases such as rubella, can also affect the development of embryos as a possible incentive for the cleft lip.
(3) the impact of endocrine early pregnancy for women using hormone therapy due to illness after the birth of the baby that is the occurrence of certain congenital malformations. In addition, children with cleft lip family history of the survey, also found that some mothers in the early stages of pregnancy had a variety of significant psychological trauma, resulting in possible inference stress response, resulting in increased secretion of adrenal cortex hormones, Induced congenital malformations.
(4) drug factors majority of drugs enter the body through the placenta into the can after the embryo. Some drugs may affect fetal development and cause deformity, known anticancer drugs (such as cyclophosphamide, methotrexate, etc.), engage in panic